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Organocatalytic Enantioselective Mannich-Type Reactions of Fluorinated Keto Esters with N-Boc-Aldimines
- Yoon, Sung Je;
- Kang, Young Ku;
- Kim, Dae Young
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59Citations
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59초록
The catalytic enantioselective Mannich reaction promoted by chiral bifunctional organocatalysts is described. The treatment of alpha-fluoro-beta-keto esters with N-Boc aldimines under mild reaction conditions afforded the corresponding beta-aminated alpha-fluoro-beta-keto esters with excellent enantioselectivities ( up to 98% ee).
키워드
Mannich reaction; asymmetric catalysis; bifunctional organocatalyst; alpha-fluoro-beta-keto esters; aldimines; ELECTROPHILIC ALPHA-AMINATION; CATALYTIC ASYMMETRIC FLUORINATION; FLUORO-BETA-KETOESTERS; MEDICINAL CHEMISTRY; CONJUGATE ADDITION; MICHAEL REACTION; 1,3-DICARBONYL COMPOUNDS; CYANO ACETATES; DIELS-ALDER; CYANOKETONES
- 제목
- Organocatalytic Enantioselective Mannich-Type Reactions of Fluorinated Keto Esters with N-Boc-Aldimines
- 저자
- Yoon, Sung Je; Kang, Young Ku; Kim, Dae Young
- 발행일
- 2011-02
- 유형
- Article
- 저널명
- Synlett
- 호
- 3
- 페이지
- 420 ~ 424
- 언어
- ENG
- 출판사
- Georg Thieme Verlag
- 발행국가
- 독일
- 분량
- 5 페이지
- ISSN
- E 1437-2096
P 0936-5214