Malignant Prostate Tissue Is Associated with Different Microbiome Gene Functions

초록

Specific microorganisms and changes in the constituents of the microbiome are linked with pathologies in humans, such as malignancy. Within the prostate, certain bacterial communities may locate advantageous conditions and establish themselves, thus outperforming alternative species. In this study, a comparison of malignant (MT) and benign prostate tissues (BT) or benign prostate hyperplasia (BPH) was performed in order to delineate the respective microbiomes in each sample type and to determine their pertinence to prostatic tumourigenesis. Specimens of MT (n = 26) and PT (n = 13)/BPH (n = 10) were acquired from patients. No variations in the make-up of the microbiome were seen when MT and PT specimens were compared. Changes in the bacterial constituents and functional genes were seen in the specimens obtained from patients with MT when contrasted against samples from those with BPH. Pelomonas was the genus with the highest abundance in MT specimens. It is proposed that dissimilar microbiome gene functions are present in the contexts of MT and PT samples.

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