Synthesis of Fluoromethyl-Substituted Cyclopentanones via Radical Fluorination and 1,2-Alkyl Migration Cascade of Alkenyl Cyclobutanols

초록

A radical fluorination/1,2-alkyl migration cascade process of alkenyl cyclobutanols was developed in this study. This approach provides a mild and convenient access to the synthesis of fluoromethyl-substituted cyclopentanone derivatives from the coupling reaction of alkenyl cyclobutanols with Selectfluor as the fluorine radical source.

키워드