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One-Pot Synthesis of 3,4-Dihydrocoumarins via C-H Oxidation/Conjugate Addition/Cyclization Cascade Reaction
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2초록
The 3,4-dihydrocoumarin derivatives were obtained from 2-alkyl phenols and oxazolones via C-H oxidation and cyclization cascade in the presence of silver oxide (Ag2O) and p-toluenesulfonic acid as a Bronsted acid catalyst. This approach provides a one-pot strategy to synthesize the multisubstituted 3,4-dihydrocoumarins with moderate to high yields (64-81%) and excellent diastereoselectivity (>20:1).
키워드
organocatalysis; one-pot reaction; ortho-quinone methides; dihydrocoumarins; oxazolones; ORTHO-QUINONE METHIDES; ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; CHIRAL DIHYDROCOUMARINS; CYCLOADDITIONS; DERIVATIVES; ALKYLATION; ALDEHYDES; ACCESS; ROUTE
- 제목
- One-Pot Synthesis of 3,4-Dihydrocoumarins via C-H Oxidation/Conjugate Addition/Cyclization Cascade Reaction
- 저자
- Kim, Dae Young
- 발행일
- 2023-10
- 유형
- Article
- 저널명
- Molecules
- 권
- 28
- 호
- 19
- 언어
- ENG
- 출판사
- Multidisciplinary Digital Publishing Institute (MDPI)
- 발행국가
- 스위스
- ISSN
- E 1420-3049
P 1420-3049