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Enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes catalyzed by binaphthyl-derived organocatalysts
- Woo, Saet Byeol;
- Kim, Dae Young
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39초록
The highly enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes, promoted by binaphthyl-modified chiral bifunctional organocatalysts is described. This reaction afforded the chiral functionalized naphthoquinones in high yields (81-95%) and excellent enantioselectivities (91-98% ee) under low catalyst loading (1 mol %).
키워드
asymmetric catalysis; Michael addition; 1,4-naphthoquinones; nitroalkenes; organocatalysis; CONJUGATE ADDITION; BETA-KETOESTERS; ALPHA,BETA-UNSATURATED KETONES; QUATERNARY STEREOCENTERS; 1,3-DICARBONYL COMPOUNDS; CYTOTOXIC EVALUATION; DERIVATIVES; CONSTRUCTION; DESIGN; ALKYLATION
- 제목
- Enantioselective Michael addition of 2-hydroxy-1,4-naphthoquinones to nitroalkenes catalyzed by binaphthyl-derived organocatalysts
- 저자
- Woo, Saet Byeol; Kim, Dae Young
- 발행일
- 2012-05-07
- 유형
- Article
- 권
- 8
- 페이지
- 699 ~ 704
- 언어
- ENG
- 출판사
- Beilstein-Institut
- 발행국가
- 독일
- 분량
- 6 페이지
- ISSN
- P 1860-5397