Organocatalytic Enantioselective Michael Addition of alpha-Nitroacetate to alpha,beta-Unsaturated Enones: A Route to Chiral gamma-Nitro Ketones and delta-Keto Esters

초록

The catalytic enantioselective conjugate addition reaction of alpha-nitroacetate to alpha,beta-unsaturated enones promoted by chiral bifunctional organocatalysts is described. The treatment of a-nitroacetate to alpha,beta-unsaturated enones afforded the corresponding Michael adducts with high enantioselectivity. The conjugate addition adducts are easily converted to chiral gamma-nitro ketones and delta-keto esters.

키워드