다양한 피부 종양에서 c-Jun과 JunB 발현에 관한 연구

초록

Background: c-Jun along with JunB, JunD, and the Fos group proteins comprise the core members of the activatorprotein 1 (AP1) family of transcription factors. Recently, many studies have demonstrated the key roles of AP1 inregulating a wide spectrum of biological processes, including tumorigenesis. We therefore hypothesized that c-Junand JunB influence the differentiation and malignant change of various skin tumors. Objective: We measured the expression levels of c-Jun and JunB in different skin tumors. Methods: The expressions of c-Jun and JunB were examined by performing the immunohistochemical staining of 55specimens of skin tumors, including 13 cases of seborrheic keratosis, 4 cases of keratoacanthoma, 9 cases of actinickeratosis, 4 cases of Bowen’s disease, 4 cases of basal cell carcinoma, 16 cases of squamous cell carcinoma, and5 cases of malignant melanoma. Results: Immunohistochemical analysis of the skin tumor tissue samples revealed a significantly higher expressionof c-Jun in malignant skin tumors (basal cell carcinoma, squamous cell carcinoma, malignant melanoma) than inbenign (seborrheic keratosis, keratoacanthoma) or premalignant skin tumors (actinic keratosis, Bowen's disease). Theexpression of JunB, however, was significantly lower in malignant skin tumors than in benign skin tumors. Conclusion: These findings showed that c-Jun has a positive association with skin malignancies, while JunB has anegative association with skin malignancies. The role of AP1 as key regulators of cell proliferation and epidermaltumor progression is suggested.

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