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Highly Enantioselective Conjugate Addition of 3-Substituted Oxindoles to Vinyl Sulfone Catalyzed by Binaphthyl-Modified Tertiary Amines
- Lee, Hyun Joo;
- Kang, Seung Hee;
- Kim, Dae Young
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55초록
The enantioselective conjugate addition reaction of 3-substituted oxindoles with 1,1-bis(benzenesulfonyl)ethylene by binaphthyl-modified bifunctional organocatalysts was investigated. The corresponding Michael adducts, containing a quaternary center at C3 position of the oxindoles, were generally obtained in high yields with excellent enantioselectivities (up to 99% ee).
키워드
oxindole; vinyl sulfone; conjugate addition; bifunctional organocatalysis; asymmetric catalysis; ASYMMETRIC MICHAEL ADDITION; MANNICH-TYPE REACTIONS; FLUORO-BETA-KETOESTERS; ALPHA,BETA-UNSATURATED KETONES; ORGANOCATALYTIC ADDITION; SQUARAMIDE DERIVATIVES; ALPHA-HYDRAZINATION; ALDEHYDES; BEARING; CONSTRUCTION
- 제목
- Highly Enantioselective Conjugate Addition of 3-Substituted Oxindoles to Vinyl Sulfone Catalyzed by Binaphthyl-Modified Tertiary Amines
- 저자
- Lee, Hyun Joo; Kang, Seung Hee; Kim, Dae Young
- 발행일
- 2011-07
- 유형
- Article
- 저널명
- Synlett
- 호
- 11
- 페이지
- 1559 ~ 1562
- 언어
- ENG
- 출판사
- Georg Thieme Verlag
- 발행국가
- 독일
- 분량
- 4 페이지
- ISSN
- E 1437-2096
P 0936-5214