Enantioselective one-pot synthesis of 2-amino-4H-chromenes via C-H oxidation and Michael addition/ring closure sequences

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초록

The chiral 2-amino-4H-chromene derivatives were obtained from 2-alkyl-substituted phenol derivatives in moderate to high yields with excellent enantioselectivities through one-pot cascade via C-H oxidation/Michael addition/ring closure sequences using a binaphthyl-modified organocatalyst with low catalyst loading (1.25 mol%).

키워드

2-Amino-4H-chromeneasymmetric catalysisorganocatalysiso-quinone methidesORTHO-QUINONE METHIDESASYMMETRIC CONJUGATE ADDITIONFRIEDEL-CRAFTS ALKYLATIONDIELS-ALDER REACTIONSBETA-KETO ACIDSMULTICOMPONENT REACTIONSDECARBOXYLATIVE ALKYLATIONCASCADE REACTIONSNITROALKENESDERIVATIVES
제목
Enantioselective one-pot synthesis of 2-amino-4H-chromenes via C-H oxidation and Michael addition/ring closure sequences
저자
Kim, Kyeong SeopKim, Dae Young
DOI
10.1080/00397911.2021.2024572
발행일
2022-01-17
유형
Article
저널명
Synthetic Communications
52
2
페이지
291 ~ 299