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Enantioselective addition of diphenyl phosphonate to ketimines derived from isatins catalyzed by binaphthyl-modified organocatalysts
- Jang, Hee Seung;
- Kim, Yubin;
- Kim, Dae Young
Citations
WEB OF SCIENCE
21Citations
SCOPUS
23초록
Chiral binaphthyl-modified squaramide-catalyzed enantioselective addition of diphenyl phosphonate to ketimines derived from isatins has been achieved. This method affords practical and efficient access to chiral 3-amino-3-phosphonyl-substituted oxindole derivatives in high yields with excellent enantioselectivities (up to 99% ee).
키워드
3-amino-3-phosphonyl-substituted oxindole; alpha-aminophosphonates; bifunctional organocatalyst; ketimines; organocatalysis; squaramide; VICINAL TETRASUBSTITUTED STEREOCENTERS; ASYMMETRIC-SYNTHESIS; ALPHA-AMINOPHOSPHONATES; TRANSFER/CYCLIZATION SEQUENCES; NATURAL-PRODUCTS; MANNICH REACTION; BETA-KETOACIDS; AMINO-ACIDS; CONSTRUCTION; TETRAHYDROQUINOLINES
- 제목
- Enantioselective addition of diphenyl phosphonate to ketimines derived from isatins catalyzed by binaphthyl-modified organocatalysts
- 저자
- Jang, Hee Seung; Kim, Yubin; Kim, Dae Young
- 발행일
- 2016-07-20
- 유형
- Article
- 권
- 12
- 페이지
- 1551 ~ 1556
- 언어
- ENG
- 출판사
- Beilstein-Institut
- 발행국가
- 독일
- 분량
- 6 페이지
- ISSN
- P 1860-5397