Organocatalytic Enantioselective Cycloaddition of o-Quinone Methides with Oxazolones: Asymmetric Synthesis of Dihydrocoumarins

초록

The organocatalytic enantioselective cycloaddition of ortho-quinone methides with oxazolones promoted by a chiral binaphthyl-modified squaramide bifunctional organocatalyst was developed, allowing an efficient synthesis of chiral dihydrocoumarins with excellent enantioselectivity (up to 97 % ee). This approach represents a practical method for the preparation of chiral 3,4-dihydrocoumarin derivatives.

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