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초록
In this study, we investigated the role of Ca2+ in curcumin-induced paraptosis, a cell death mode that is accompanied by dilation of mitochondria and the endoplasmic reticulum (ER). Curcumin induced mitochondria! Ca2+ overload selectively in the malignant breast cancer cells, but not in the normal breast cell, contributing to the dilation of mitochondria/ER and subsequent paraptotic cell death. In addition, we found that simultaneous inhibition of the mitochondrial Na+/Ca2+ exchanger (mNCX) and proteasomes can trigger a sustained mitochondrial Ca2+ overload and effectively induce paraptosis in malignant breast cancer cells. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
키워드
Paraptosis; Curcumin; Mitochondrial Ca2+; Proteasomal inhibition; Breast cancer; ENDOPLASMIC-RETICULUM STRESS; CURCUMIN INDUCES APOPTOSIS; OXIDATIVE STRESS; IN-VITRO; CALCIUM; DEATH; ANTICANCER; RESISTANCE; RELEASE; ACTIVATION
- 제목
- Simultaneous mitochondrial Ca2+ overload and proteasomal inhibition are responsible for the induction of paraptosis in malignant breast cancer cells
- 저자
- Yoon, Mi Jin; Kim, Eun Hee; Kwon, Taeg Kyu; Park, Sun Ah; Choi, Kyeong Sook
- 발행일
- 2012-11-28
- 유형
- Article
- 저널명
- Cancer Letters
- 권
- 324
- 호
- 2
- 페이지
- 197 ~ 209