Handgrip strength as a predictor of new-onset cardiovascular disease: insights from the Korean genome and epidemiology study (KoGES) cohort

초록

Background and aims: Handgrip strength (HGS) has been identified as a predictor of various comorbidities, including pneumonia, chronic kidney disease, and cancer. Additionally, HGS has been associated with the prevalence of cardiovascular disease (CVD). However, the usefulness of HGS as an indicator of incident CVD remains unclear. Methods: In this nationwide cohort study, 173,195 subjects were enrolled and followed for 4.1 years. A total of 35,664 participants were included in the final analysis. During the follow-up, 131 participants developed cerebrovascular disease, 401 experienced coronary heart disease (CHD), and 526 developed CVD. Anthropometric, laboratory, and lifestyle factors were assessed in relation to CVD risk. Results: Participantswere categorised into quartiles based on their relative handgrip strength (RGS). Cox regression analyses revealed an inverse association between RGS and new-onset cerebrovascular disease, CHD, and CVD. After controlling for confounders, the hazard ratios (HRs) [95 % confidence intervals (CIs)] for new-onset CHD were 0.63 (0.41-0.98) in men and 0.50 (0.26-0.95) in women. Additionally, after adjusting for confounders, the HRs [95 % CIs] for incident CVD in the highest quartile (Q4)were 0.68 (0.47-1.00) in men and 0.50 (0.28-0.89) in women. As RGS increased, the incidence of CHD and CVD significantly decreased, with stronger associations observed in women. Discussion and Conclusions: This novel study demonstrates an association between RGS and incident CHD and CVD, with stronger significance in women. In clinical settings, RGS can be a useful surrogate markerof CHD and CVD, and regular assessments may help detect these conditions early.

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