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Catalytic enantioselective chlorination of cyclic beta-keto esters in the presence of chiral Pd(II) complexes
- Kang, Young Ku;
- Kim, Hee Hun;
- Koh, Kwang Oh;
- Kim, Dae Young
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31Citations
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33초록
The catalytic enantioselective electrophilic chlorination promoted by chiral palladium complexes is described. The treatment of beta-keto esters with 2,3,4,5,6,6-hexachlorocyclohex-2,4-dienone as chlorine source under mild reaction conditions afforded the corresponding a-chlorinated beta-keto esters with excellent enantioselectivities (up to 94% ee). (C) 2012 Elsevier Ltd. All rights reserved.
키워드
Chlorination; Asymmetric catalysis; Chiral palladium catalysts; beta-Keto esters; MANNICH-TYPE REACTIONS; ASYMMETRIC ALPHA-CHLORINATION; CONJUGATE ADDITION; ELECTROPHILIC FLUORINATION; CARBONYL-COMPOUNDS; ALPHA,BETA-UNSATURATED KETONES; CINCHONA ALKALOIDS; KETOESTERS; PHOSPHONATES; AMINATION
- 제목
- Catalytic enantioselective chlorination of cyclic beta-keto esters in the presence of chiral Pd(II) complexes
- 저자
- Kang, Young Ku; Kim, Hee Hun; Koh, Kwang Oh; Kim, Dae Young
- 발행일
- 2012-07-18
- 유형
- Article
- 권
- 53
- 호
- 29
- 페이지
- 3811 ~ 3814
- 언어
- ENG
- 출판사
- Elsevier BV
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- P 0040-4039