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Asymmetric Synthesis of Tetrahydroquinolines via 1,5-Hydride Transfer/Cyclization Catalyzed by Chiral Primary Amine Catalysts
- Kang, Young Ku;
- Kim, Dae Young
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93초록
Chiral primary amine-catalyzed asymmetric CH functionalization has been achieved. In this process, enantiotopic Csp(3)H functionalization at the -position to the nitrogen atom of 4-[ortho-(dialkylamino)phenyl]but-3-en-2-one is activated by chiral 9-amino(9-deoxy)-epi-quinine to afford tetrahydroquinine derivatives with high enantioselectivities (up to 97% ee).
키워드
asymmetric synthesis; CH functionalization; 1; 5-hydride transfer; organocatalysis; tetrahydroquinolines; H BOND FUNCTIONALIZATION; RING-CLOSURE REACTIONS; HYDRIDE TRANSFER; C-C; TRANSFER HYDROGENATION; STEREOCHEMICAL ASPECTS; HETEROCYCLIC SYNTHESIS; CARBONYL-COMPOUNDS; ALPHA-CYCLIZATION; TERTIARY-AMINES
- 제목
- Asymmetric Synthesis of Tetrahydroquinolines via 1,5-Hydride Transfer/Cyclization Catalyzed by Chiral Primary Amine Catalysts
- 저자
- Kang, Young Ku; Kim, Dae Young
- 발행일
- 2013-11-11
- 유형
- Article
- 권
- 355
- 호
- 16
- 페이지
- 3131 ~ 3136
- 언어
- ENG
- 출판사
- John Wiley & Sons Ltd.
- 발행국가
- 독일
- 분량
- 6 페이지
- ISSN
- E 1615-4169
P 1615-4150