Lipoprotein Lipase Polymorphism rs10503669 is Associated with High-density Lipoprotein Cholesterol Levels in Korean Population

초록

High-density lipoprotein (HDL) cholesterol levels are associated with decreased risk of coronary artery disease. Several genome-wide association studies (GWAS) for HDL cholesterol levels have implicated Lipoprotein lipase (LPL)as possibly being causal. Herein, the association between single nucleotide polymorphism (SNP) rs10503669 in the LPLgene and HDL cholesterol levels and triglyceride levels was tested in the Korean population. A total of 994 subjectsfrom Seoul City were included in a replication study with LPL SNP rs10503669. SNP rs10503669 in the LPL gene wasassociated with mean HDL cholesterol levels (effect per allele 3.13 mg/dL, P<0.0001) and triglyceride levels (effect perallele -18.0 mg/dL, P=0.0026). Subjects with the CA/AA genotype had a 0.42-fold (range 0.23~0.77-fold) lower riskof having abnormal HDL cholesterol levels (<40 mg/dL) than subjects with the CC genotype. When analyzed bygender, the association of LPL was stronger in men than in women. This study clearly demonstrates that genetic variantsin LPL influence HDL cholesterol levels and triglyceride levels in Korean adults.

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