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A new duet in cancer biology: AMPK the typical and UBE2O the atypical
- Vila, Isabelle K.;
- Song, Su Jung;
- Song, Min Sup
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7초록
Ubiquitin-conjugating enzyme E2O (UBE2O) is upregulated in human cancers. We have demonstrated that genetic deletion or pharmacological blockade of UBE2O reduces tumorigenesis through inhibiting the mammalian target of rapamycin complex 1-hypoxia-inducible factor 1-alpha pathway. Critically, UBE2O targets adenosine monophosphate (AMP)-activated protein kinase-alpha 2 (AMPK alpha 2) for ubiquitination and degradation. We thus suggest the UBE2O-AMPK alpha 2 axis as a potential therapeutic target for cancer.
키워드
AMPK; AMPK alpha 2; arsenite; breast cancer; cancer metabolism; HIF1 alpha; mTOR; prostate cancer; UBE2O; ubiquitination; TUMOR-SUPPRESSOR; UBIQUITINATION
- 제목
- A new duet in cancer biology: AMPK the typical and UBE2O the atypical
- 저자
- Vila, Isabelle K.; Song, Su Jung; Song, Min Sup
- 발행일
- 2017
- 유형
- Editorial Material
- 저널명
- MOLECULAR & CELLULAR ONCOLOGY
- 권
- 4
- 호
- 3