Electrochemical C-H Oxidation/Conjugate Addition/Cyclization Sequences of 2-Alkyl Phenols: One-Pot Synthesis of 2-Amino-4H-chromenes

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초록

Electrochemical C-H oxidation/conjugate addition/cyclization sequences of 2-alkyl phenols with malononitrile are described. This transformation is an environmentally friendly approach by successfully avoiding the use of stoichiometric amounts of external redox reagents. Various 2-amino-4H-chromene derivatives are afforded in moderate to high yields through a one-pot process from 2-benzyl or 2-cinnamyl phenol derivatives under mild reaction conditions.

키워드

2-Alkyl phenols2-amino-4H-chromeneselectrochemical reactionortho-Quinone methidesORTHO-QUINONE METHIDESFRIEDEL-CRAFTS ALKYLATIONDIELS-ALDER REACTIONSBETA-KETO ACIDSASYMMETRIC-SYNTHESISENANTIOSELECTIVE SYNTHESISMULTICOMPONENT REACTIONSDECARBOXYLATIVE ALKYLATIONELECTROCATALYTIC APPROACHCYCLOADDITION REACTION
제목
Electrochemical C-H Oxidation/Conjugate Addition/Cyclization Sequences of 2-Alkyl Phenols: One-Pot Synthesis of 2-Amino-4H-chromenes
저자
Kim, Kyeong SeopKim, Dae Young
DOI
10.1002/ajoc.202200486
발행일
2022-11
유형
Article
저널명
Asian Journal of Organic Chemistry
11
11