The Apical Junctional Complex in Respiratory Diseases

초록

The epithelium, including the respiratory system, acts as a selective gate between theoutside environment and underlying tissue. Epithelial cells are polarized due to theformation of the apical junctional complex, which includes adherent junctions and tightjunctions. Endothelial cells are one of the most important cellular constituents of bloodvessels. Endothelial junctional proteins play important roles in tissue integrity as wellas in vascular permeability, leukocyte extravasation, and angiogenesis. This reviewfocuses on the apical junctional complex in respiratory diseases.

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