Synthesis of Trifluoromethylated 4H-1-Benzopyran Derivatives via Photocatalytic Trifluoromethylation/Oxidation/Conjugate Addition, and Cyclization Sequences of Vinyl Phenols

초록

The objective of this study was to describe a cyclization reaction of photoredox generated ortho-quinone methides using 1,3-diketones for the synthesis of trifluoromethylated 4H-1-benzopyrans with moderate to high yields. This process resulted in in situ formation of trifluoromethylated ortho-quinone methides from 2-vinyl phenols with Umemoto's reagent, followed by conjugate addition and cyclization reaction of 1,3-diketones.

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