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Catalytic Enantioselective Friedel-Crafts Alkylation of Indoles with Fumarate Derivatives in the Presence of Chiral Palladium Complexes
- Lee, Hyun Joo;
- Kim, Dae Young
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27초록
The catalytic enantioselective Friedel-Crafts alkylation reaction promoted by chiral palladium complexes is described. The treatment of indoles with fumarate derivatives under the mild reaction conditions afforded the corresponding Friedel-Crafts alkylation adducts with high enantioselectivities (up to 91% ee).
키워드
Friedel-Crafts reaction; asymmetric catalysis; chiral palladium catalysts; indoles; fumamate derivatives; MANNICH-TYPE REACTIONS; BETA-KETO-ESTERS; CONJUGATE ADDITION; ALPHA,BETA-UNSATURATED KETONES; CARBONYL-COMPOUNDS; ACID CATALYSIS; ASYMMETRIC-SYNTHESIS; ALPHA-HYDROXYLATION; MICHAEL ADDITION; PHOSPHORIC-ACID
- 제목
- Catalytic Enantioselective Friedel-Crafts Alkylation of Indoles with Fumarate Derivatives in the Presence of Chiral Palladium Complexes
- 저자
- Lee, Hyun Joo; Kim, Dae Young
- 발행일
- 2012-07
- 유형
- Article
- 저널명
- Synlett
- 호
- 11
- 페이지
- 1629 ~ 1632
- 언어
- ENG
- 출판사
- Georg Thieme Verlag
- 발행국가
- 독일
- 분량
- 4 페이지
- ISSN
- E 1437-2096
P 0936-5214