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Catalytic asymmetric Mannich-type reactions of fluorinated ketoesters with N-Boc aldimines in the presence of chiral palladium complexes
- Kang, Young Ku;
- Kim, Dae Young
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68초록
The catalytic enantioselective Mannich reaction promoted by chiral palladium complexes is described. The treatment of alpha-fluoro-beta-ketoesters with N-Boc-aldimines under mild reaction conditions afforded the corresponding beta-aminated alpha-fluoro-beta-ketoesters with excellent enantioselectivities (up to 99% ee). (C) 2011 Elsevier Ltd. All rights reserved.
키워드
Mannich reaction; Asymmetric catalysis; Chiral palladium catalysts; alpha-Fluoro-beta-ketoesters; Aldimines; ENANTIOSELECTIVE CONJUGATE ADDITION; ELECTROPHILIC ALPHA-AMINATION; BETA-KETO PHOSPHONATES; MEDICINAL CHEMISTRY; MICHAEL REACTION; 1,3-DICARBONYL COMPOUNDS; DIELS-ALDER; ESTERS; CYANOKETONES; DERIVATIVES
- 제목
- Catalytic asymmetric Mannich-type reactions of fluorinated ketoesters with N-Boc aldimines in the presence of chiral palladium complexes
- 저자
- Kang, Young Ku; Kim, Dae Young
- 발행일
- 2011-05-04
- 유형
- Article
- 권
- 52
- 호
- 18
- 페이지
- 2356 ~ 2358
- 언어
- ENG
- 출판사
- Elsevier BV
- 발행국가
- 영국
- 분량
- 3 페이지
- ISSN
- P 0040-4039