A 12-Week, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lactobacillus plantarum LMT1-48 on Body Fat Loss

초록

Objectives: This study aims to evaluate the efficacy and safety of probiotics for body fat reduction in obese individuals. Methods: A total of 106 participants with a body mass index between 25 and 30 kg/m2 were randomly assigned to either the experimental group treating with Lactobacillus plantarum LMT1-48 or the placebo group in the placebo-controlled clinical trial. Body composition was assessed by dual-energy X-ray absorptiometry and computed tomography. Fecal samples between the groups were contrasted via DNA sequencing for evaluation of the microbiota and its diversity. Results: After 12 weeks of follow-up period, the body fat mass decreased significantly, from 30.0 +/- 4.4 to 28.3 +/- 4.1 kg in the experimental group (p = 0.009). The percentage of body fat in the two groups showed a similar trend (p = 0.004). Conclusions: LMT1-48 also positively influenced the microbial taxa linked to obesity analyzed by gut microbiome sequencing. LMT1-48 is a safe and collaborative agent to reduce obesity.

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