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Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst
- Lee, Hyun Joo;
- Woo, Saet Byeol;
- Kim, Dae Young
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WEB OF SCIENCE
27Citations
SCOPUS
29초록
The enantioselective conjugate addition reaction of 3-aryl-substituted oxindoles with methyl vinyl ketone promoted by binaphthyl-modified bifunctional organocatalysts was investigated. The corresponding Michael adducts, containing a quaternary center at the C3-position of the oxindoles, were generally obtained in high yields with excellent enantioselectivities (up to 91% ee).
키워드
oxindole; methyl vinyl ketone; conjugate addition; bifunctional organocatalysis; asymmetric catalysis; MANNICH-TYPE REACTIONS; ELECTROPHILIC ALPHA-AMINATION; FLUORO-BETA-KETOESTERS; CONJUGATE ADDITION; ASYMMETRIC-SYNTHESIS; ALPHA,BETA-UNSATURATED KETONES; QUATERNARY STEREOCENTERS; 3-SUBSTITUTED OXINDOLES; CARBENE LIGANDS; ALKYLATION
- 제목
- Enantioselective Michael Addition of 3-Aryl-Substituted Oxindoles to Methyl Vinyl Ketone Catalyzed by a Binaphthyl-Modified Bifunctional Organocatalyst
- 저자
- Lee, Hyun Joo; Woo, Saet Byeol; Kim, Dae Young
- 발행일
- 2012-06
- 유형
- Article
- 저널명
- Molecules
- 권
- 17
- 호
- 6
- 페이지
- 7523 ~ 7532