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Enantio- and diastereoselective Michael addition reactions of alpha-cyanoketones to nitroalkenes catalyzed by binaphthyl-derived organocatalyst
- Lee, Hyun Joo;
- Woo, Saet Byeol;
- Kim, Dae Young
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42초록
The catalytic enantioselective and diastereoselective Michael addition reactions promoted by chiral bifunctional organocatalysts are described. The treatment of alpha-cyanoketones with nitroalkenes under mild reaction conditions afforded the corresponding gamma-niro alpha-cyanoketones with excellent diastereoselectivities (up to syn/anti >99/1) and excellent enantioselectivities (up to 99% ee). (C) 2012 Elsevier Ltd. All rights reserved.
키워드
Organocatalysis; Michael reaction; Asymmetric catalysis; Cyanoketones; Nitroalkenes; MANNICH-TYPE REACTIONS; ENANTIOSELECTIVE CONJUGATE ADDITION; BETA-KETO-ESTERS; ALPHA,BETA-UNSATURATED KETONES; QUATERNARY STEREOCENTERS; 1,3-DICARBONYL COMPOUNDS; ASYMMETRIC-SYNTHESIS; HIGHLY EFFICIENT; CYANO ACETATES; KETOESTERS
- 제목
- Enantio- and diastereoselective Michael addition reactions of alpha-cyanoketones to nitroalkenes catalyzed by binaphthyl-derived organocatalyst
- 저자
- Lee, Hyun Joo; Woo, Saet Byeol; Kim, Dae Young
- 발행일
- 2012-06-27
- 유형
- Article
- 권
- 53
- 호
- 26
- 페이지
- 3374 ~ 3377
- 언어
- ENG
- 출판사
- Elsevier BV
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- P 0040-4039