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Enantioselective decarboxylative Michael addition of beta-ketoacids to nitroalkenes catalyzed by binaphthyl-derived organocatalysts
- Moon, Hyoung Wook;
- Kim, Dae Young
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69초록
The catalytic enantioselective decarboxylative Michael addition reaction promoted by chiral bifunctional organocatalysts has been developed, allowing facile synthesis of the corresponding gamma-nitro ketones with excellent enantioselectivity (up to 97% ee). The method reported represents a valuable approach utilizing beta-ketoacids as synthetic equivalents of aryl methyl ketones. (C) 2012 Elsevier Ltd. All rights reserved.
키워드
Asymmetric catalysis; Organocatalysis; Michael addition; gamma-Nitro ketones; Nitroalkenes; MANNICH-TYPE REACTIONS; FRIEDEL-CRAFTS ALKYLATION; PRIMARY AMINE-THIOUREAS; ACID HALF-THIOESTERS; CONJUGATE ADDITION; KETO-ESTERS; POLYKETIDE SYNTHASES; ALPHA-NITROACETATE; ALDOL REACTIONS; NITROOLEFINS
- 제목
- Enantioselective decarboxylative Michael addition of beta-ketoacids to nitroalkenes catalyzed by binaphthyl-derived organocatalysts
- 저자
- Moon, Hyoung Wook; Kim, Dae Young
- 발행일
- 2012-11-28
- 유형
- Article
- 권
- 53
- 호
- 48
- 페이지
- 6569 ~ 6572
- 언어
- ENG
- 출판사
- Elsevier BV
- 발행국가
- 영국
- 분량
- 4 페이지
- ISSN
- P 0040-4039