Correlation of Cardiac Markers and Biomarkers With Blood Pressure of Middle-Aged Marathon Runners

초록

Runners with exercise-induced high blood pressure have recently been reported to exhibit higher levels of cardiac markers, vasoconstrictors, and inflammation. The authors attempted to identify correlations between exercise-related personal characteristics and the levels of biochemical/cardiac markers in marathon runners in this study. Forty healthy runners were enrolled. Blood samples were taken both before and after finishing a full marathon. The change in each cardiac/biochemical marker over the course of the marathon was determined. All markers were significantly (P<.001) increased immediately after the marathon (creatine kinase-MB [CK-MB]: 7.9 +/- 2.7ng/mL, cardiac troponin I (cTnI): 0.06 +/- 0.10ng/mL, N-terminal pro-B-type natriuretic peptide (NT-proBNP): 95.7 +/- 76.4, endothelin-1: 2.7 +/- 1.16, high-sensitivity C-reactive protein [hs-CRP]: 0.1 +/- 0.09, creatine kinase [CK]: 315.7 +/- 94.0, lactate dehydrogenase [LDH]: 552.8 +/- 130.3) compared with their premarathon values (CK-MB: 4.3 +/- 1.3, cTnI: 0.01 +/- 0.003, NT-proBNP: 27.6 +/- 31.1, endothelin-1: 1.11 +/- 0.5, hs-CRP: 0.06 +/- 0.07, CK: 149.2 +/- 66.0, LDH: 399 +/- 75.1). In middle-aged marathon runners, factors related to increased blood pressure were correlated with marathon-induced increases in cTnI, NT-proBNP, endothelin-1, and hs-CRP. These correlations were observed independent of running history, records of finishing, and peak oxygen uptake. (C) 2015 Wiley Periodicals, Inc.

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