Visible-light-mediated photocatalytic difluoroalkylation/1,2-carbon migration sequences: synthesis of difluoroalkyl-substituted cyclic ketones

Suh, Chang Won; Kim, Dae Young

doi:10.1016/j.tetlet.2015.08.068

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Visible-light-mediated photocatalytic difluoroalkylation/1,2-carbon migration sequences: synthesis of difluoroalkyl-substituted cyclic ketones

Suh, Chang Won;
Kim, Dae Young

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WEB OF SCIENCE

54

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SCOPUS

56

초록

A visible-light-mediated photocatalytic ethoxycarbonyldifluoromethylation/1,2-carbon migration of alkenols is described. This approach provides a mild and operationally simple access to the synthesis of difluoralkyl-substituted cyclic ketones via difluoralkylation and 1,2-carbon migration of 1-(1-arylvinyl) cyclobutanol derivatives. (C) 2015 Published by Elsevier Ltd.

키워드

Difluoroalkylation; Photocatalysis; Radical reaction; 1,2-Carbon migration; ONE-POT SYNTHESIS; PHOTOREDOX CATALYSIS; ASYMMETRIC-SYNTHESIS; ALLYLIC ALCOHOLS; ENANTIOSELECTIVE FLUORINATION; ORGANOCATALYTIC SYNTHESIS; COMBINING PHOTOREDOX; MEDICINAL CHEMISTRY; 1,2-ARYL MIGRATION; TRIFLUOROMETHYLATION

제목: Visible-light-mediated photocatalytic difluoroalkylation/1,2-carbon migration sequences: synthesis of difluoroalkyl-substituted cyclic ketones

저자: Suh, Chang Won; Kim, Dae Young

DOI: 10.1016/j.tetlet.2015.08.068

발행일: 2015-10-07

유형: Article

저널명: Tetrahedron Letters

권: 56

호: 41

페이지: 5661 ~ 5664

언어: ENG

출판사: Elsevier BV

발행국가: 영국

분량: 4 페이지

ISSN: P 0040-4039